Purpose: The purpose of this study was to examine the effects of parental stress, social support, and coping behavior on burnout among motherscaring for children with cerebral palsy. Methods: Participants in this cross-sectional, descriptive study were 185 mothers who completed aself-report structured questionnaire. The data were analyzed using descriptive statistics, t-test, one-way ANOVA, correlation and multiple linearregression analyses with IBM SPSS Win 22 program. Results: Parental stress and coping behavior were strong predictors of burnout amongmothers of children with cerebral palsy. These variables explained 50.0% of the variance in burnout. Social support was not a predictor of burnout. A higher level of burnout was associated with higher levels of parental stress and lower levels of social support and coping behavior. Conclusion:Mothers of children with cerebral palsy are vulnerable to burnout. These results show that effective strategies for reducing parentalstress and improving positive coping behavior are needed to reduce burnout in these mothers.