Purpose: The purpose of this study was to verify effects of the Empowering A Self-Efficacy (EASE) program on self-efficacy, self-management,and child attitude toward illness in children with epilepsy. Methods: This was a quasi-experimental study with a non-equivalentcontrol group pre-post test design. Participants were 10 to 15 year old children with epilepsy (11 in the experimental group and 10 in thecontrol group) who were registered at one hospital in S city. The experimental group received the EASE program for 3 weeks. In the firstweek, a group meeting lasting 570 minutes was conducted on a single day. Over the next two weeks, telephone counselling was conductedtwice a week. Data were analyzed using SPSS 18.0. Results: There was a significant difference of pre-post evaluation of the epilepsyself-management scores in the experimental group. However, differences between the experimental group and the control groupfor seizure self-efficacy and child attitude toward illness were not significant. Conclusion: This is the first study in Korea to develop andevaluate an intervention program for children with epilepsy. Further studies are needed to confirm the effects of the EASE program.