Purpose: To identify the effects of foot reflexology massage on fatigue, stress and depression of postpartum women. Methods: Anonequivalent control group pre-post design was used. A total of 70 women in a postpartum care center were recruited and wereassigned to the experimental group (35) or control group (35). Foot reflexology massage was provided to the experimental grouponce a day for three days. Data were collected before and after the intervention program which was carried out from December,2013 to February, 2014. Data were analyzed using Chi-square test, Fisher’s exact test, and t-test. Results: The level of fatigue in theexperimental group was significantly lower than the control group (t= - 2.74, p =.008). The level of cortisol in the urine of women inthe experimental group was significantly lower than the control group (t= - 2.19, p =.032). The level of depression in the experimentalgroup was significantly lower than the control group (t= - 3.00, p =.004). Conclusion: The results show that the foot reflexologymassage is an effective nursing intervention to relieve fatigue, stress, and depression for postpartum women.