Purpose: This paper reports the results of a hospital centered follow-up program on parenting stress, parenting efficacy and copingfor mothers with very low birth weight (VLBW) infants. Methods: The follow-up program consisted of home visiting by an expertgroup and self-help program for 1 year. A non-equivalent control group pre-post quasi-experimental design was used. Participantswere 70 mothers with low birth weight infants and were assigned to one of two groups, an experimental groups (n=28), which receivedthe family support program; and a control group (n=27), which received the usual discharge education. Data were analyzedusing χ 2-test, t-test, and ANCOVA with IBM SPSS statistics 20.0. Results: Mothers’ parenting stress (F=5.66, p =.004) was significantlydecreased in the experimental group. There were also significant increases in parenting efficacy (F=13.05, p qqqlt;.001) and coping(F=8.91, p =.002) in the experimental group. Conclusion: The study findings suggest that a follow-up program for mothers withVLBW infants is an effective intervention to decrease mothers’ parenting stress and to enhance parenting efficacy and coping.