Purpose: This study was conducted to develop a program to help emergency nurses overcome compassion fatigue, and to analyzethe effects of the program. Methods: A nonequivalent control group pretest-posttest design was used. There were 14 participants inthe experimental group and 18 subjects in the control group. The program was comprised of five, weekly 80-minute sessions includingunderstanding and assessment of compassion fatigue, enhancing positive affect, balancing work-life, planning self care, trainingin relaxation techniques and cognitive restructuring, and getting social support. Research variables were ego-resiliency, compassionsatisfaction and compassion fatigue of the ProQOL 5, and salivary cortisol. Data were analyzed using Chi-square test, independentt-test, and paired t-test. Results: The first hypothesis, “There will be a difference in scores for ego resiliency between the experimentalgroup and the control group”. was not supported. The second hypothesis, “There will be a difference in scores for compassionsatisfaction between the experimental group and the control group” was supported (t=2.15, p =.046). The third hypothesis,“There will be a difference in scores for compassion fatigue between the experimental group and the control group” was not supported. Conclusion: The first program for emergency nurses to overcome compassion fatigue in Korea was effective in increasingemergency nurses’ compassion satisfaction and decreasing salivary cortisol level in the experimental group. Therefore, this programfor overcoming compassion fatigue is useful to increase emergency nurses’ compassion satisfaction. However replication studies ofshort-term intensive program reflecting emergency nurses’ opinion are needed.