Purpose: This study was conducted to develop an Empowerment Education Program (EEP) for kidney transplant patients and to test the program’seffects on uncertainty, self-care ability, and compliance. Methods: The research was conducted using a nonequivalent control groupwith a pretest-posttest design. The participants were 53 outpatients (experimental group: 25, control group: 28) who were receiving hospitaltreatment after kidney transplants. After the pre-test, patients in the experimental group underwent a weekly EEP for six weeks. The post-testwas conducted immediately after, and four weeks after the program’s completion in the same manner as the pre-test. For the control group,we conducted a post-test six and ten weeks after the pre-test, without and program intervention. A repeated measure ANOVA was performedto compare the change scores on main outcomes. Results: Uncertainty was significantly lower in the experimental group than in the controlgroup, both immediately after (t=-3.84, p=qqqlt;.001) and 4 weeks after (t=-4.51 p=qqqlt;.001) the program, whereas self-care ability (t=5.81, p=qqqlt;.001),(t=5.84, p=qqqlt;.001) and compliance (t=5.07, p=qqqlt;.001), (t=5.45, p=qqqlt;.001) were significantly higher. Conclusion: Kidney transplant patients who underwentan EEP showed a decrease in uncertainty and an improvement in self-care ability and compliance. Thus, our findings confirmed thatan EEP can be an independent intervention method for improving and maintaining the health of kidney transplant patients.