Purpose: To identify the effects of a smart program for the patients who underwent percutaneous coronary intervention (SP-PCI) on coronarydisease-related knowledge, health behaviors, and quality of life. Methods: A nonequivalent control group with a non-synchronized design wasutilized and 48 participants (experimental=22, control=26) were recruited from a university hospital in Gyeongsang area from May to December,2016. The 12-week SP-PCI consisted of self-study of health information using smart phone applications (1/week), walking exercise (qqqgt;5/week) usingsmart band, feedback using Kakao talk (2/week), and telephone counseling (1/week). Patients in the control group received usual care fromtheir primary health care providers and a brief health education with basic self-management brochure after the PCI. Data were analyzed usingthe SPSS 21.0 program through descriptive statistics,χ2test, and t-test. Results: After the 12-week SP-PCI, the experimental group showed higherlevels of coronary disease-related knowledge (t=2.43, p=.019), heart-related health behaviors (t=5.96, pqqqlt;.001), regular exercise (Z=-4.47,pqqqlt;.001), and quality of life-MCS (t=3.04, p=.004) and showed lower levels of stress (Z=-3.53, pqqqlt;.001) and sodium intake (t=-4.43, pqqqlt;.001) thanthose in the control group. There were no significant group differences in medication adherence and food intake in total energy, lipids, and cholesterol. Conclusion: The suggested SP-PCI provided easy access and cost-effective intervention for patients after PCI and improved their knowledgeof the disease, performance of health behaviors, and quality of life. Further study with a wider population is needed to evaluate the effectsof SP-PCI on disease recurrence and quality of life for patients after PCI.