Objectives: This study performed to analyze general characteristics, environmental factors, and health promoting lifestyle by smoking behavior among university students. Methods: In 2011, interview survey was conducted with 700 Korean students of university and college in located 7 metropolitan cities and the biggest province (Gyeonggido). To examine the factors related to smoking behavior, it collected environmental factors, health promoting lifestyle, and mental health. Multiple logistic regression analysis for survey data identified the difference of smoking behavior. Results: The 20.4% of university students was current smoker. Smoking rate of male was higher than that of female. The university students residing in Seoul and surrounding areas were less likely to have smoking behavior than them residing in local areas. In multiple regression models, difference by gender, academic year, college level, college type, region, secondary smoking exposure time, health status, monthly drinking, alcohol use disorder, and eating breakfast remained significantly (pqqqlt;0.01, pqqqlt;0.05). Conclusion: Future efforts should be focused on association between health risk factors and environment factors in physical, mental, and social aspects. To achieve this, we will need to provide the integrated health promotion program to decrease smoking problems of university students.