Objectives: This study performed to analyze health promotion practices and mental health related to high risky drinking behavior and alcohol use disorder among first-year students of university. Methods: To examine the association with drinking behavior, mental health and health promotion practices, health survey was conducted with 3,918 students who were first-year students in an university by self-reported questionnaire from February 26 to March 10, 2015. Multiple logistic regression analysis performed to identify the difference of mental health and health promotion practices by drinking behavior. Results: 2,570 students (65.6%) were monthly drinker and 445 students (11.4%) were high risk drinker. The 40% (n=1,566) of them was alcohol use disorder and the 11.9% (n=466) was current smoker. In multiple logistic regression models, it remained significantly the difference of drinking behavior and alcohol use disorder by gender, drunk driving experience, current smoking, secondhand smoke exposure hour (1 hour or more per 1 day), BMI, eating habit, physical activity and sleeping hour (pqqqlt;.05, pqqqlt;.01). On the other hand, it was not significant the difference by stress level, depression and suicidal thoughts. Conclusions: To improve the health promotion practice of first-year students of university, it should provide the comprehensive healthcare program and alcohol policy to reduce harmful drinking behavior on the university campus.