Objectives: The purpose of this study was to investigate the relationship between suicidal ideation and experience with drug among Korean adolescents using data from the 12th 2016 Korea youth risk behavior web-based survey. Methods: The subjects were 32,219 middle school students and 33,309 high school students, there were 65,528 people in total. The Data were analyzed by frequency, χ2 test and multiple logistic regression analysis using SPSS complex samples Win 23 program. Results: The prevalence of suicidal ideation and experience with drug was 12.1%, 0.9% respectively. The statistically significant difference between suicidal ideation and experience with drug were found. In the final model, the significant factors influencing experience with drug were suicidal ideation, economic state, type of residence, agony counselor, hospital treatment experience through violence, experience with alcohol, experience with smoking, perceived stress and experience sad or despair for the last 12 months for two weeks. Conclusions: Based on these results, factors identified in this study need to be considered in programs directed at prevention of suicidal ideation and experience with drug management in Korean adolescents, and to validate its effects.