This study was focused on investigating the factors of the psychological adaptation of grandmothers raising their grandchildren. The Double ABCX family stress model provided the theoretical basis for this study, and the major factors examined in the study included a pile-up of stressors, family resources and social support, appraisal of situation(redefinition of nurturing), and adaptation(depressive mood and happiness). Data were collected by personal interview with 213 grandmothers raising their grandchildren utilizing the questionnaire survey method. Structural equation modeling analyses were performed and the results showed that a pile-up of stressors, the family resources(i.e., contact and emotional solidarity with grandchildren"s parents), and the redefinition of nurturing had significant influences on the psychological adaptation of grandmothers raising their grandchildren. It was also found that social support had indirect influence on grandmothers" psychological adaptation. The redefinition of nurturing had the greatest effect on the participants" psychological adaptation, followed by a pile-up stressor, and then the family resources.