The purpose of this study was to identify the relationships between Healthy Family Support Center (HFSC) program participation and family strengths and program needs based on HFSC participants’ individual, family, and community characteristics. A total of 695 HFSC participants who were married and had participated in HFSC programs were recruited through 25 local HFSCs in Seoul. A multiple regression method was conducted for data analysis. The major findings are as follows. Family strengths was related to the variables of age, education, monthly household income, and participation in family counseling and sharing family care programs. In terms of program needs, the variables of marital conflict, difficulty in care, financial distress, family strengths, and family-friendly community were associated with HFSC program needs while participants’ socio-demographic characteristics were not related to program needs. This study highlights that HFSC programs have different target populations considering that the level of family strengths was different among the various programs’ participants. In addition, program needs are different depending upon the HFSC participants’ experiences in the family and community. These findings suggest that it is important to consider participants’ family and community characteristics as well as participants’ socio-demographic characteristics to provide appropriate programs for all HFSC participants.