The purpose of this study is to explore the relative influence of psychological well-being and social support on the burnout of infant care teachers. Participants were 194 infant care teachers from 52 infant daycare centers in Gyeong-gi-do. Psychological burnout was assessed by the Maslach Burnout Inventory(Lee, 2011), psychological well-being was measured by the Psychological well-being scale(Cho qqqamp; Cha, 2001) and social support was measured by the social support questionnaire(Bak, 1985). Date were analyzed using descriptive statistics and analysis, t-test, Pearson's correlation analysis, and multiple regression analysis. The major results of this study were as follows; First, there were differences in burnout in terms of marital status, work experiences, classroom operation type and income. Second, Infant care teachers' burnout was negatively correlated with psychological well-being and social support. Third, the most influential factor on infant care teachers' burnout was purpose in life, the second most influential factor was self-acceptance, the third most influential factor was emotional support, and the least influential factor was environmental mastery. Results of this study indicate that a psychological well-being enhancement program should be developed and emotional support from a social relationship network should be enhanced in order to prevent infant care teachers' burnout.