한국보건사회연구원 전자도서관

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기사

Learning, Private Information, and the Economic Evaluation of Randomized Experiments /

개인저자
Chan, Tat Y. ;, Hamilton, Barton H.
수록페이지
997-1040 p.
발행일자
2006.12.18
출판사
University of Chicago Press
초록
[영문]Many randomized experiments are plagued by attrition, even among subjects receiving more effective treatments. We estimate the subject’s utility associated with the receipt of treatment, as revealed by dropout behavior, to evaluate treatment effects. Utility is a function of both “publicly observed” outcomes and side effects privately observed by the subject. We analyze an influential AIDS clinical trial, ACTG 175, and show that for many subjects, AZT yields the highest level of utility despite having the smallest impact on the publicly observed outcome because of mild side effects. Moreover, although subjects enter the experiment uncertain of treatment effectiveness (and often the treatment received), the learning process implies that early dropout in ACTG 175 is primarily driven by side effects, whereas later attrition reflects declining treatment effectiveness.