Purpose: Acute myocardial infarction (AMI) leads to death if the patient does not receive emergency treatment. Thus it is very importantto recognize the symptoms in the early stage. The purpose of this study was to identify clusters of symptoms that representAMI in Koreans. Methods: The study used a retrospective, descriptive design with secondary data analysis. Data were abstractedfrom 725 medical records of AMI patients admitted from June 1, 2006 to August 15, 2014 at a university hospital. Results: Analysis ofthe AMI symptoms revealed five symptom clusters; Cluster 1 (n=140): middle chest pain (100%), shortness of breath, and coldsweating, Cluster 2 (n=256): substernal pain (100%), cold sweating, and shortness of breath, Cluster 3 (n=47): substernal pain(95.7%), left arm pain, shortness of breath, cold sweating, left shoulder pain, right arm pain, and the lower neck pain, Cluster 4(n=212): shortness of breath (28.3%), left chest pain, and upper abdominal pain, and Cluster 5 (n=70): cold sweating (100%), leftchest pain, shortness of breath, left shoulder pain, and upper abdominal pain. Length of hospital stay and mortality rate were significantlydifferent according to symptom clusters (F=2.52, p=.040; F=3.62, p=.006, respectively). Conclusion: Symptom clusters ofAMI from this study can be used for AMI patients in order to recognize their symptoms at an early stage. The study findings shouldbe considered when developing educational prevention programs for Koreans with AMI.