Purpose: The purpose of this study, which was guided by the Resiliency Model of Family Stress, Adjustment, and Adaptation, wastwofold: (a) to explore family and parental adaptation and factors influencing family adaptation in Korean families of children withDown syndrome (DS) through a quantitative methodology and (b) to understand the life with a Korean child with DS through aqualitative method. Methods: A mixed-methods design was adopted. A total of 147 parents of children with DS completed a packageof questionnaires, and 19 parents participated in the in-depth interviews. Quantitative and qualitative data were analyzed usingstepwise multiple regression and content analysis respectively. Results: According to the quantitative data, the overall family adaptationscores indicated average family functioning. Financial status was an important variable in understanding both family and parentaladaptation. Family adaptation was best explained by family problem solving and coping communication, condition managementability, and family hardiness. Family strains and family hardiness were the family factors with the most influence on parental adaption. Qualitative data analysis showed that family life with a child with DS encompassed both positive and negative aspects and wasexpressed with 5 themes, 10 categories, and 16 sub-categories. Conclusion: Results of this study expand our limited knowledge andunderstanding concerning families of children with DS in Korea and can be used to develop effective interventions to improve theadaptation of family as a unit as well as parental adaptation.