Purpose: The purpose of this study was to develop and evaluate a self-management program based on INR monitoring for patientswith cardiac valve replacement. Methods: This program was comprised of five weekly sessions based on Sousa’s Enhance-BehaviorPerformance Model. The first session included individual teaching, and the other four sessions included Prothrombin time InternationalNormalized Ratios (PT INR) self-monitoring, telephone counseling and self-management checklist recording. Participants werepatients who had cardiac valve replacement. They were randomly assigned to the experimental or control group. Sixteen in the experimentalgroup participated in the self-management program and seventeen in the control group participated in general care. Selfmanagementknowledge, self-efficacy, self-management behavior and PT INR were measured as dependent variables. Data were analyzedusing Mann Whitney U-test, t-test and ANCOVA. Results: The experimental group showed significantly higher post-test scoresin self-management knowledge (t=5.86, p qqqlt;.001), self-efficacy (F=18.32, p qqqlt;.001), and self-management behavior (t=3.44, p =.002)compared to the control group. Also, the experimental group showed significantly higher frequency in maintaining the treatmentrange of PT INR compared to the control group (χ 2=4.80, p =.028). Conclusion: The results of the research on the self-managementprogram based on PT INR monitoring showed that it is effective in improving self-management knowledge, self-efficacy, and selfmanagementbehavior as well as maintaining treatment range of PT INR of patients with cardiac valve replacement.