Purpose: The purpose of this study was to construct and test a structural equation model of quality of work life for clinical nurses basedon Peterson and Wilson’s Culture-Work-Health model (CWHM). Methods: A structured questionnaire was completed by 523 clinicalnurses to analyze the relationships between concepts of CWHM-organizational culture, social support, employee health, organizationalhealth, and quality of work life. Among these conceptual variables of CWHM, employee health was measured by perceived health status,and organizational health was measured by presenteeism. SPSS21.0 and AMOS 21.0 programs were used to analyze the efficiencyof the hypothesized model and calculate the direct and indirect effects of factors affecting quality of work life among clinical nurses. Results: The goodness-of-fit statistics of the final modified hypothetical model are as follows: χ 2=586.03, χ 2/df=4.19, GFI=.89, AGFI=.85,CFI=.91, TLI=.90, NFI=.89, and RMSEA=.08. The results revealed that organizational culture, social support, organizational health, andemployee health accounted for 69% of clinical nurses’ quality of work life. Conclusion: The major findings of this study indicate that it isessential to create a positive organizational culture and provide adequate organizational support to maintain a balance between thehealth of clinical nurses and the organization. Further repeated and expanded studies are needed to explore the multidimensional aspectsof clinical nurses’ quality of work life in Korea, including various factors, such as work environment, work stress, and burnout.