Purpose: The focus of this study was on symptom management to predict quality of life among individuals with heart failure. Thetheoretical model was constructed based on situation-specific theory of heart failure self-care and literature review. Methods: Forparticipants, 241 outpatients at a university hospital were invited to the study from May 19 to July 30, 2014. Data were collectedwith structured questionnaires and analyzed using SPSSWIN and AMOS 20.0. Results: The goodness of fit index for the hypotheticalmodel was .93, incremental fit index, .90, and comparative fit index, .90. As the outcomes satisfied the recommended level, the hypotheticalmodel appeared to fit the data. Seven of the eight hypotheses selected for the hypothetical model were statistically significant. The predictors of symptom management, symptom management confidence and social support together explained 32% ofthe variance in quality of life. The 28% of variance in symptom management was explained by symptom recognition, heart failureknowledge and symptom management confidence. The 4% of variance in symptom management confidence was explained by socialsupport. Conclusion: The hypothetical model of this study was confirmed to be adequate in explaining and predicting of qualityof life among patients with heart failure through symptom management. Effective strategies to improve the quality of life amongpatients with heart failure should focus on symptom management. Symptom management can be enhanced by providing educationalprograms, encouraging social support and confidence, consequently improving quality of life among this population.