Purpose: This study was done to develop a internalized stigma reducing program based on cognitive-behavioral therapy and appropriatefor patients with schizophrenia and to evaluate its effectiveness. Methods: The study design was a mixed method research. Qualitativestudy, 13 patients with schizophrenia who had experience in overcoming stigma were purposively chosen for interviews and data were analyzedusing Giorgi method. Quantitative study, 64 patients with schizophrenia (experimental group =32, control group =32) were recruited. The cognitive-behavioral therapy-based program for reducing internalized stigma in patients with schizophrenia was provided for 8weeks (12 sessions). Data were collected from June. 20, 2013 to Feb. 14, 2014. Quantitative data were analyzed using χ ²-test, t-test, repeatedmeasures ANOVA with the SPSS program. Results: Qualitative results, from the experience of coping with stigma in patients withschizophrenia seventeen themes and five themes-clusters were drawn up. Quantitative results showed that internalized stigma, self-esteem,mental health recovery and quality of life were significantly better in the experimental group compared to the control group. Conclusion:Study findings indicate that this program for reducing internalized stigma in patients with schizophrenia is effective and can berecommended as a rehabilitation program intervention to help patients with schizophrenia to cope with internalized stigma.