Purpose: This concept analysis was done to clarify ‘uncertainty in epilepsy’. Methods: Walker and Avant’s methodology guided the analysis. In addition,the concept was compared with uncertainty in other health problems. Results: ‘Uncertainty in epilepsy’ was defined as being in the conditionas seen from the epilepsy experience where cues were difficult to understand because they changed, were in discord with past ones, orthey had two or more contradictory values at the same time. Uncertainty in epilepsy is evolved from appraisal of the epilepsy experience. As aresult, uncertainty leads epilepsy patients, their family or health care providers to impaired functioning and proactive/passive coping behavior. Conclusion: Epilepsy patients with uncertainty need to be supported by nursing strategies for proactive, rational coping behavior. This achievementhas implications for interventions aimed at changing perception of epilepsy patients, their families or health care providers who must dealwith uncertainty.