Purpose: This study was conducted to assess the reliability and validity of the Korean version of the Coping and Adaptation Processing Scale- Short- Form in patients with cancer. Methods: The original scale was translated into Korean using Brislin’s translation model. The Korean Short- Form and the Functional Assessment Cancer Therapy-General were administered to 164 Korean patients with cancer using convenience sampling method. The collected data were analyzed using SPSS 23.0 and AMOS 23.0. Construct validity, criterion validity, test-retest reliability, and internal consistency reliability of the Korean Coping and Adaptation Processing Scale-Short-Form were evaluated. Results: Exploratory factor analysis supported the construct validity with a four-factor solution that explained 60.6% of the total variance. Factor loadings of the 15 items on the four subscales ranged .52~.86. The four-subscale model was validated by confirmatory factor analysis (Normed χ2=1.38 (p =.013), GFI=.92, SRMR=.02, RMSEA=.05, TLI=.4, and CFI=.95), and criterion validity was demonstrated with the Functional Assessment Cancer Therapy-General. Cronbach’s alpha for internal consistency of the total scale was .83 and ranged .68~.81 for all subscales, demonstrating sufficient test-retest reliability. Conclusion: The Korean version showed satisfactory construct and criterion validity, as well as internal consistency and test-retest reliability.