Objectives: This study purposed to identify the factors influencing health promotion behavior in college students. The research design was descriptive study. Methods: Data were collected through structured questionnaires. The participants of this study were 368 college students in B qqqamp; U metropolitan city and C city. Data were collected from October 5 to October 20, 2013. The data were analyzed using t-test, ANOVA, Scheffe"s test, Pearson"s correlation coefficients, and Stepwise multiple regression with SPSS WIN v 20.0. Results: The mean scores of psychosocial stress, self-efficacy, perceived health status, health promotion behavior were 1.05±0.45, 2.97±0.41, 3.45±0.74, 3.35±0.47 respectively. Factors influencing health promotion behavior of the participants were found to be psychosocial stress, ways to relieve stress, age, self-efficacy, perceived health status and spending money. These factors explained 47.8% of variance in the participants’ health promotion behavior. Conclusions: Based on this program, we suggest that nursing intervention programs enhancing psychosocial stress, self-efficacy, and perceived health status for college students should be developed to improve their health promotion behavior.