Objectives: The aim of this study was to identify the associations with social support, stress coping strategy and depression among some urban middle-aged men and women. Methods: Considering the regional distribution 4 districts of Seoul were conveniently selected for this study and a total of 329 middle-aged men and women participated in the self-administered survey. The survey questionaries included social support, stress coping strategy, depression and general characteristics. Results: Avoidance and problem solving strategies were significant independent variables to the men’s depression scores, but social support was not significant. However middle aged female’s social support more explained the variance of the depression scores than the problem solving strategy. Conclusions: Significant sociopsychological factors that affected middle-aged depression were different by sex and according to the results, stress coping strategy for men and social support for woman were significant factors on depression control in urban middle-aged population.