Objectives: The purpose of study was to evaluate the effectiveness of infographics in health communication and to identify the factors affecting effectiveness. Methods: The structured questionnaire, based on Rogers' Diffusion of Innovation theory, was developed to identify factors affecting the effectiveness of infographics in health communication. 715 respondents divided into two groups received a combination of infographics and text message to see the effectiveness of infographics as compared to textual messages. The characteristics of the group with the highest and the lowest effectiveness of infographics were analyzed through decision tree. Results: The effectiveness of infographics in health communication compared with textual data was 3.36-3.57, which showed a positive attitude toward infographics in all aspects. The group with the highest effectiveness of infographics showed high scores for preferences on contents, trialability of data and ease of understanding. The group with the lowest effectiveness of infographics was over 45 years old and showed lower scores for preferences on contents and individual compatibility. Conclusions: Based on the results of the study, the application of infographics could be recommended to improve the effectiveness of health messages. Also, it was suggested that various strategies should be developed to maximize the effectiveness of information communication by the characteristics of the participants.