[영문]Objectives:The aim of this study was to elucidate, whether shift from first generation antipsychotics (FGA) to olanzapine can affect health-related quality of life (HRQoL) of residually symptomatic schizophrenic outpatients.Methods:Patients were randomized to either olanzapine or to continuation on their FGA. The 15D-measured HRQoL at baseline and end-point (after 12 weeks) was compared.Results:Patients (n= 21) randomized to olanzapine achieved better HRQoL than those (n= 21) who continued on their FGA. This difference on the 15D (0.048 on a 0?1 scale; p= .037) was clinically important and comparable to that resulting from common surgical interventions, for example, hip or knee replacement.Conclusions:HRQoL of stable outpatients with residual symptoms or adverse effects may improve substantially after shift from FGAs to olanzapine.