This study investigates the effect of self-control on college life adjustment of college students. We explore the mediating effects of emotional coping and behavioral coping on the relations between self-control and college life adjustment. We selected 375 college students as participants from Daegu and Gyeongsan cities. Collected data was analyzed by descriptive statistics, Pearson’s correlation, structural equational models, and Sobel test with SPSS software ver. 21.0 and Amos software ver. 21.0. The major findings are as follow. First, self-control had significant effect on college life adjustment. Second, emotional coping and behavioral coping mediated between self-control and college life adjustment. In addition, there were significant differences between male college students and female college students regarding the relation between self-control and college life adjustment. While male college student’s emotional coping had a greater influence than that of female college students, female college student’s behavioral coping had a greater influence than that of male college students. The findings of this study suggest that intervention to address emotional coping and behavioral coping are important to resolve male and female college students’ college life adjustment; in addition, gender should be considered to understand college life adjustment.