Purpose: This study was done to develop an empowerment program for people with chronic mental illness and to analyze effects ofthe program on level of empowerment. Methods: The research was conducted using a nonequivalent control group pretest-posttestdesign. Participants were 37 people with chronic mental illness (experimental group: 18, control group: 19). The empowerment programwas provided for 8 weeks (15 sessions). Data were collected between July 21 and October 17, 2014. Data were analyzed usingChi-square, Fisher’s exact test, Sapiro-wilk test, and Repeated measure ANOVA with SPSS/WIN 18.0. Results: Quantitative resultsshow that self-efficacy, interpersonal relationships, attitudes in the workplace, occupational performance capacity, and levels ofempowered execute were significantly better in the experimental group compared to the control group. Conclusion: Study findingsindicate that this empowerment program for persons with chronic mental illness is effective for improving self efficacy, interpersonalskills, attitudes in the workplace, occupational performance capacity, levels of empowered execute.