Objectives : The main objectives of this research is to reveal the mediating effects of subjective health rates on the relationship between stress and life satisfaction of the persons with mental illness. Methods : This study used the data from 2011 Disabled survey by Ministry of health and welfare. The study subjects were 98,801 persons with mental illness. Mediating effects of subjective health rate was analyzed using regression analysis and sobel test. Results: The stress was negatively correlated with the subjective health rates and life satisfaction. And the subjective health rates was positively correlated with life satisfaction. Second, the subjective health rates worked as partial mediators on the relationship between stress and life satisfaction of the persons with mental illness. The implication and limitations of this study were discussed, and suggestions for further study were proposed. Conclusion: This study highlights that the mediating effects of subjective health rates on the relationship between stress and life satisfaction of the persons with mental illness. Health and welfare policy encouraging subjective health rates and reducing level of the stress to improve life satisfaction of the persons with mental illness should be considered.