The purpose of this study is to analyze the history of regulatory policy changes in food safety sector with enactment and amendment status of laws, enforcement ordinances, and enforcement regulations and to propose the appropriate direction of regulatory policy for enhanced food safety management. Regulation is defined in two ways. First, regulation in a narrow sense is a government interference in the market mechanism. Second, regulation in a broad sense is not limited to the economic area, but connotes overall government interventions for the maintenance of social order. With budget and administrative organization, regulation is counted as a role of "Hidden tax." Regulation can be classified according to characteristics and standard of regulation registration. Classifications of regulation by characteristics are economic regulations (2,695 cases), social regulations (2,302 cases), and administrative regulations (1,955 cases). Also, regulations divided by standard of regulation registration are main regulations and subordinate regulations. Total 202 cases of enactment and amendment of Food Sanitation Law has been made from its first enactment in 1962 to the first half year of 2013. Until 1998, continuous regulations andestablishment of new regulations were mainstream than deregulation or abolition. After enforcement of total emission regulation, which abolished 50% of existed regulations, by Kim, Dae-Jung Government, food safety regulation had been weakened with such as abolition of regulations. Also, base of food safety management had been weakened as well. Since then, enhancing and establishing regulations have been leaded as the main trend to cope with enhancing food safety management, harmonizing international standards, and expanding food safety management area. Especially, under the "National Happiness" which is a national keynote by present government, enhancing and establishing regulations are expected in priority in food regulatory rationalization for eradication of unsanitary food. According to investigation of perception on food regulatory, complaints on frequent establishment and amendment of law showed 3.82 points out of 5 points. Establishing and enhancing the regulatory have been used for government policy instrument. Since food safety has become a new social risk, the importance of food regulatory is growing fast. Therefore, it is right time to promote enhanced regulatory policy in food safety. Rationalization of regulations including enhancing safety regulations and mitigating or abolishing regulation procedure in food safety sector is needed.